配方 开发和评估Cannabidiol热挤出固体自乳化药物输送系统的口服应用
Kavish Sanil1, Ahmed Almotairy2, Prateek Uttreja1
1Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, Mississippi, 38677, USA.
AAPS PharmSciTech
|June 11, 2024
概括
热挤出 (HME) 技术被用来创建固体自乳化药物输送系统 (SEDDS) 对于大麻素 (CBD). 这种方法显著改善了CBD的CBD.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 大麻素研究 研究 大麻素研究
背景情况:
- 大麻二醇 (CBD) 由于溶解度低和广泛的第一通代谢,具有较差的口服生物利用性.
- 提高CBD交付的传统方法在可扩展性和效率方面面临挑战.
研究的目的:
- 调查热挤出 (HME) 的使用,以连续生产固体自乳化药物输送系统 (SEDDS),用于大麻素 (CBD).
- 提高CBD的可溶性,体外溶解和口服生物可用性.
主要方法:
- 使用HME与诸如芝麻油,Poloxamer 188,Gelucire®59/14,PEO N80和Soluplus®等辅助剂一起开发含有CBD的固体SEDDS.
- 描述SEDDS配方,包括乳化时间,滴滴大小分析和体外溶解研究.
- 在不同温度下 (4°C,25°C,40°C) 在60天内评估配方的稳定性.
主要成果:
- SEDDS配方 (F1和F2) 呈现出快速乳化 (约9分钟) 并形成具有小液滴大小 (150-400纳米) 的乳液.
- 实验室溶解率显著提高,90% (F1) 和83% (F2) 的CBD在一小时内释放,而纯CBD则为14%.
- 配方F1在4°C下60天内表现出稳定性.
结论:
- 连续热挤出 (HME) 是生产固体SEDDS的可行技术,为传统方法提供了替代方案.
- 经HME处理的SEDDS显著改善了Cannabidiol (CBD) 的体外溶解和潜在的口服输送.
- 通过SEDDS进行增强的CBD输送有望改善治疗结果.
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