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在结直肠癌中,BATF促进瘤进展和与FDG PET衍生的参数的关联

Xia Lu¹, Jun Liu¹, Lijuan Feng¹

¹Department of Nuclear Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.

Journal of translational medicine

|June 11, 2024

概括

基本氨酸拉链ATF类转录因子 (BATF) 在结直肠癌 (CRC) 中表达高,与预后不佳有关. BATF表达与¹⁸F-FDG PET/CT参数相关,SUV_max可以预测BATF水平.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
医疗成像医学成像

背景情况:

结肠直肠癌 (CRC) 在全球范围内仍然是一个重大的健康问题.
了解与CRC进展和成像特征相关的分子标记物对于改善诊断和治疗至关重要.

研究的目的:

在结直肠癌 (CRC) 中研究基本氨酸拉链ATF类转录因子 (BATF) 的表达和功能.
确定BATF表达和2-deoxy-2[¹⁸F]fluoro-D-glucose (¹⁸F-FDG) 定子发射断层扫描/计算机断层扫描 (PET/CT) 参数之间的相关性.

主要方法:

使用TIMER,GEPIA,TCGA和GEO数据库对BATF表达的生物信息分析.
在体外研究涉及逆转录定量PCR,西部污染,基因沉默,细胞计数工具包-8测定和CRC细胞系中的克隆基因测定.
在CRC患者组织中对BATF和GLUT-1进行免疫组织化学检查,以及与手术前的F-FDG PET/CT参数的相关性.

主要成果:

在包括CRC在内的泛癌分析中,BATF的表达很高,并且与预后不佳有关.
在试验室中,BATF倒置抑制了CRC细胞的增殖.
瘤BATF表达在CRC组织上调,与GLUT-1,瘤大小,SUV_max,MTV和TLG正相关. SUV_max独立预测了BATF的表达.

结论:

在CRC中,BATF可能起到瘤基因的作用,并且与特定的F-FDG PET/CT成像特征有关.
在F-FDG PET/CT上的最大标准吸收值 (SUV_max) 可以作为CRC中BATF表达的独立预测因子.

关键词:

在18F-FDG中.在BATF中,BATF是BATF.结肠直肠癌是一种癌症.一个进步的进步.

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