针对多发性骨髓瘤中的mTOR信号通路:生物学和对治疗的影响
Yanmeng Wang1, Niels Vandewalle1, Kim De Veirman1,2
1Translational Oncology Research Center (TORC) - Team Hematology and Immunology (HEIM), Vrije Universiteit Brussel (VUB), Jette, Belgium.
Cell communication and signaling : CCS
|June 11, 2024
概括
多发性骨髓瘤 (MM) 细胞表现出强烈的蛋白质合成,受哺乳动物目标拉巴胺素 (mTOR) 途径的调节. 针对mTOR复合体提供了潜在的策略来克服这种无法治愈的癌症中耐药性的可能性.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 细胞信号传输 细胞信号传输
背景情况:
- 多发性骨髓瘤 (MM) 是一种血液性恶性瘤,其特点是耐药性和依赖高蛋白合成.
- 哺乳动物的拉巴胺素 (mTOR) 途径的目标,包括mTORC1和mTORC2复合体,调节关键的细胞过程,如蛋白质合成和新陈代谢.
- 在MM中观察到异常的mTOR激活,有助于癌细胞存活和治疗耐药性.
研究的目的:
- 在多发性骨髓瘤的背景下,提供mTOR途径的结构,调节和功能的全面概述.
- 突出mTOR在蛋白质合成和MM病原发生中的作用.
- 总结目前针对MM中mTOR的治疗策略,并确定挑战.
主要方法:
- 本综述综合了关于mTOR途径的现有研究和最近的发现.
- 它讨论了mTOR复合体的结构和监管方面.
- 研究了mTOR参与蛋白质合成和MM的机制.
主要成果:
- mTOR是蛋白质合成的关键调节剂,是MM细胞的标志.
- mTOR复合体的失调与MM细胞的存活率和对治疗的抗性有关.
- 了解mTOR调节对于开发新型MM治疗至关重要.
结论:
- mTOR途径是多发性骨髓瘤的关键参与者,影响细胞存活率和耐药性.
- 准mTOR复合体为MM提供了一个有前途的治疗途径.
- 需要进一步的研究来克服与MM的mTOR向疗法相关的挑战.
相关概念视频
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
PI3K/mTOR/AKT Signaling Pathway
3.5K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
3.5K
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Interactions Between Signaling Pathways
6.3K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
Non-Canonical Wnt Signaling Pathways
7.3K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.3K


