解读瘤微环境中的巨细胞的表现:呼吁精确免疫疗法
Belén Toledo1,2, Linrui Zhu Chen2, María Paniagua-Sancho3,4,5,6
1Department of Health Sciences, University of Jaén, Campus Lagunillas, Jaén, E-23071, Spain.
Journal of hematology & oncology
|June 11, 2024
概括
瘤相关巨细胞 (TAMs) 在癌症中具有双重作用,促进或抑制瘤的进展. 向TAM为癌症免疫疗法提供了潜力,但有效治疗仍然面临挑战.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
背景情况:
- 瘤相关巨细胞 (TAMs) 是瘤微环境 (TME) 中的免疫细胞.
- TAMs表现出不同的亚群,主要是M1 (抗瘤) 和M2 (前瘤) 现型.
- TAMs影响瘤生长,血管新生,转移和化学抵抗.
研究的目的:
- 审查关于巨细胞起源,功能和TME相互作用的文献.
- 为了探索巨细胞两极化路径和调节性刺激.
- 评估目前基于巨细胞的临床干预及其局限性.
主要方法:
- 关于巨细胞生物学和TME相互作用的综合文献综述.
- 对巨细胞两极化机制和刺激的分析.
- 评估针对TAMs的现有临床策略.
主要成果:
- TAMs具有双重作用,对支持和反瘤的过程作出贡献.
- 巨细胞极化是由TME衍生因素动态调节的.
- 目前的干预措施,如增强细胞或M1极化,显示出有希望的结果,但面临着障碍.
结论:
- 针对TAM是精确瘤学中一个有前途的战略.
- 克服TAM导向疗法的挑战对于有效的免疫疗法至关重要.
- 需要进一步的研究来优化基于巨细胞的癌症治疗.
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