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Updated: Jun 24, 2025

Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes
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Published on: January 12, 2024

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集成定堆和层次动力学:MSICDA驱动的CREBBPodomain抑制

Xinpei Wang1, Xu Chen1, Zhidong Chen1

  • 1School of Pharmaceutical Sciences, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China.

Journal of chemical information and modeling
|June 12, 2024
PubMed
概括

我们开发了一种新的计算方法,即多尺度整合性结构动力学评估 (MSICDA),用于设计接 (SP). 这种方法确定了强大的SPs,DA#430和DA#99409,与现有的抑制剂相比,对CREBBP-BrD的疗效有所改善.

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