在儿童中 Omicron 和 Delta SARS-CoV-2 感染的临床严重程度
David Chun-Ern Ng1, Chuin-Hen Liew2, Kah Kee Tan3
1Department of Pediatrics, Hospital Tuanku Ja'afar, Seremban, Malaysia.
概括
患有COVID-19住院儿童的Omicron变异感染比Delta变异感染更严重. 奥米克朗病例显示出更高的,和下呼吸道感染率,需要更多的医疗资源.
科学领域:
- 儿童传染病 儿童传染病
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 在COVID-19的住院儿童中比较Omicron和Delta变种感染的临床特征和严重程度.
- 评估儿科COVID-19变种之间的疾病表现和结果的差异.
研究的目的:
- 为了比较感染Omicron和Delta SARS-CoV-2变种的儿童之间的临床表现,疾病严重程度和医疗资源利用情况.
- 在儿科COVID-19住院治疗中,确定与每个变体相关的特定症状和并发症.
主要方法:
- 从2021年1月到2022年3月,对COVID-19患者住院儿童 (≤12岁) 的回顾性分析.
- 针对基线特征对抗的Omicron和Delta病例的倾向性得分匹配 (1:1) ,不包括先前感染,接种疫苗或同时感染.
- 评估临床特征,治疗方法和疾病严重程度,使用适应的世卫组织顺序尺度.
主要成果:
- 与Delta相比,Omicron感染与发作 (OR 10.87),发作 (OR 8.39) 和下呼吸道感染 (OR 2.32) 的几率更高.
- 奥米克朗病例显示中度/重度疾病的可能性增加 (OR 6.14) 和更多需要静脉注射液体,皮质类固醇,抗生素和氧气治疗.
- 匹配分析包括558对儿科患者,最初确定668例德尔塔和699例Omicron感染.
结论:
- 与Delta相比,患有Omicron COVID-19的住院儿童表现出明显的临床特征.
- 儿童的Omicron感染与疾病严重程度的增加和医疗保健资源利用率的提高有关.
- 研究结果强调,需要根据循环变种为儿童COVID-19量身定制的临床管理策略.
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