艾斯凯特胺与基于正念的干预相结合,用于患有酒精问题的个人
Emily M Gent1, Joshua W Bryan1, Maisy A Cleary1
1Psychopharmacology and Addiction Research Centre, Haighton Research Centre, University of Exeter St Luke's Campus, Exeter, UK.
Journal of psychopharmacology (Oxford, England)
|June 12, 2024
概括
埃斯凯特胺改善了对酒精使用障碍的正念治疗的参与,从而减少了渴望. 这表明,通过加深冥想练习的参与,埃斯基坦胺可能会提高治疗结果.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 成 药物 药物 药物 药物
背景情况:
- 酒精使用障碍 (AUD) 是一个重大的公共卫生问题,具有严重的个人和社会影响.
- 基他胺辅助疗法对AUD有希望,但它的作用机制需要进一步阐明.
- 了解药理学药剂如何与行为疗法相互作用,对于优化成治疗至关重要.
研究的目的:
- 对于滥用酒精的人来说,研究结合基于正念的干预 (MBI) 的乙胺的疗效.
- 为了确定埃斯基坦胺是否增强了AUD患者对MBI的参与.
- 评估加强MBI参与对与酒精有关的结果的影响.
主要方法:
- 这是一项双盲试点研究,涉及28名患有酒精问题的参与者.
- 随机分配,以接受舌下乙胺化物或安慰剂 (维生素C口服薄膜).
- 两周的每日MBI,评估正念,MBI参与,酒精渴望和消费.
主要成果:
- 与安慰剂相比,Esketamine显著增加了与每日MBI的心理参与.
- 接受乙胺治疗的参与者经历了酒精渴望的暂时减少.
- 乙胺的使用与显著更大的神秘和离散体验有关.
结论:
- 当与基于正念的疗法相结合时,Esketamine可能会提高AUD的治疗结果.
- 增加对冥想实践的参与似乎是埃斯基坦胺发挥其作用的关键机制.
- 需要进一步的研究,以探索胺在成治疗中的治疗潜力.
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