患有免疫球蛋白A血管炎的儿童病的临床特征和危险因素
Boonyapohn Chatpaitoon1, Pornpimol Rianthavorn2, Ankanee Chanakul2
1Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
概括
10岁以上的儿童,肥胖和高血压预测IgA血管炎炎 (IgAVN). 至少一年的密切监测对于高危IgA血管炎 (IgAV) 患者至关重要.
科学领域:
- 儿科脏病学 儿科脏病学
- 类风湿病学 类风湿病学
- 系统性血管炎是什么?
背景情况:
- 免疫球蛋白A (IgA) 血管炎 (IgAV),以前称为埃诺克-申莱因紫外线 (HSP),是一种常见的儿童系统性血管炎.
- 脏干扰 (IgAV炎,IgAVN) 显著增加患病率,并与长期的不良结果有关.
- 了解IgAVN的风险因素对于儿科患者的早期检测和管理至关重要.
研究的目的:
- 描述IgAV的临床和实验室特征与儿童的脏参与.
- 确定与IgAV炎 (IgAVN) 发展相关的重大风险因素.
- 为诊断出IgAV.儿童的临床监测策略提供信息.
主要方法:
- 这是一项双向描述性研究,涉及77名被诊断患有IgAV的儿童.
- 从电子医疗记录收集数据 (2010年1月至2022年12月) 包括人口统计,临床症状和实验室结果.
- 使用多变量逻辑回归和卡普兰-梅尔生存分析来确定风险因素和炎发病的时间.
主要成果:
- 在研究的IgAV患者中,IgAV炎 (IgAVN) 在32.4%的患者中发生.
- 关键的脏干扰指标包括微观血 (100%),脏范围蛋白尿 (44%) 和非脏蛋白尿 (40%).
- 对IgAVN的预测因素是年龄>10岁 (AHR 4.66),肥胖 (BMI z-score ≥ +2 SDs) (AHR 3.59) 和高血压在发病时 (AHR 4.78).
结论:
- 10岁以上的儿童,肥胖者和患有高血压的儿童患IgAVN的风险明显更高.
- 大多数IgAV患者在疾病发病后的前9个月内发生炎.
- 建议在患有这些风险因素的IgAV患者进行至少一年的持续监测.
更多相关视频
09:43Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
2.9K
07:35Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
11.5K
相关概念视频
Renal Corpuscle
1.9K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.9K
Nephrons
2.3K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.3K
External Anatomy of the Kidney
1.0K
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
1.0K
Factors Affecting Renal Clearance: Renal Impairment
84
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
84
Internal Anatomy of the Kidney
1.6K
The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
1.6K
