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能量平衡与奖励系统基因多态性和年轻墨西哥受试者的食欲特征之间的关系
Ingrid Rivera-Iñiguez1,2, Claudia Hunot-Alexander2, Maricruz Sepúlveda-Villegas1
1Department of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara, "Fray Antonio Alcalde", Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco, Mexico.
Frontiers in nutrition
|June 12, 2024
概括
在COMT,MC4R和FTO中的遗传变异会影响年轻成年人的食欲特征,如情绪过度进食和不充分进食. 这些发现可能会为打击肥胖和饮食失调的个性化策略提供信息.
科学领域:
- 遗传学和营养学
- 行为科学 行为科学
- 肥胖问题研究研究
背景情况:
- 受遗传学和环境影响的食欲特征在能量平衡和食物奖励中发挥作用.
- 了解这些特征的遗传基础对于解决体重管理和饮食行为至关重要.
研究的目的:
- 研究与能量平衡和食物奖励通路以及墨西哥年轻成年人的食欲特征相关的基因多态性之间的关联.
- 确定可能使个体倾向于情绪过度进食或不充分进食的特定遗传变异.
主要方法:
- 这是一项涉及118名大学本科生的横截面研究.
- 评估食欲特征使用成人饮食行为调查问卷的西班牙语说者 (AEBQ-Esp).
- 在LEP,MC4R,FTO,GHRL,DRD2/ANKK1和COMT中使用实时PCR对多态的基因型定型.
主要成果:
- 携带Met等位基因的携带者表现出明显更高的"情绪过度进食"分数.
- MC4R CC+CT基因型与"情绪过度进食"正相关,并与更高的风险相关.
- 保护性FTO TT基因型与"情绪低食"正相关,并与更高的风险有关.
结论:
- 特定的COMT,MC4R和FTO基因型与年轻成年人的"情绪过度饮食"和"情绪不足饮食"有关.
- 这些遗传因素可能会通过享乐饮食和减少腹感来影响体重增加.
- 需要在不同的人群和生命阶段进行进一步的研究,以开发个性化的营养遗传策略,以预防饮食失调和肥胖.
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