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与癌症相关的纤维细胞和T细胞之间的相互作用:功能交叉与向和生物标志物潜在的交叉

Vladan Milosevic¹, Arne Östman^1,2

¹Department of Clinical Medicine, University of Bergen, Bergen, Norway.

Upsala journal of medical sciences

|June 12, 2024

概括

癌症相关纤维细胞 (CAFs) 通过重塑瘤微环境并直接抑制T细胞来抑制抗癌免疫力. 向CAF可能为癌症治疗提供新的治疗策略.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
细胞生物学细胞生物学

背景情况:

癌症相关纤维细胞 (CAF) 是瘤微环境 (TME) 的关键调节者.
CAFs影响细胞外基质 (ECM) 改造,癌症进展和免疫反应.
它们在调节抗癌免疫力,特别是T细胞反应中的作用越来越被认可.

研究的目的:

审查CAFs的免疫调节功能.
总结CAFs抑制T细胞介导的抗癌免疫力的机制.
突出CAF作为预后生物标志物和治疗点的潜力.

主要方法:

对CAF及其在TME中的相互作用研究的文献综述.
分析CAF对免疫细胞的影响,重点是T细胞.
检查CAF使用的直接和间接抑制机制.

主要成果:

通过与巨细胞和树突细胞 (DCs) 相互作用,CAFs创造了一个免疫抑制的环境.
CAFs通过ECM重塑,免疫检查点表达,细胞因子分泌和细胞外囊泡直接抑制T细胞的抗癌能力.
通过CAF介导的效应会损害T细胞的增殖,存活,迁移,分化,并导致疲.

结论:

CAFs显著影响T细胞功能和抗癌免疫力.
特定的CAF子集在不同癌症中表现出不同的免疫调节能力.
CAFs代表了新型癌症免疫疗法和预后标志物的有希望的目标.

关键词:

与癌症相关的纤维细胞 (CAF).这些T细胞是T细胞.瘤免疫力免疫力瘤微环境 (TME) 是一种微环境.

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