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身体外膜氧化电路对雷梅西维尔的影响
Jeffrey J Cies1,2,3, Wayne S Moore1, Jillian Deacon2
1The Center for Pediatric Pharmacotherapy LLC (JJC, WSM, AC), Pottstown, PA.
概括
雷美西维尔 (RDV) 损失发生在体外膜氧化 (ECMO) 电路中,在较大的3/8英寸电路中药物减少更大. 氧化器是一种氧化器.
科学领域:
- 药理动力学 药理动力学
- 生物医学工程 生物医学工程
- 临界护理医学 临界护理医学
背景情况:
- 身体外膜氧化 (ECMO) 是一种用于重症患者的生命支持技术.
- 雷梅西维尔 (Remdesivir,简称RDV) 是一种用于治疗某些病毒感染的抗病毒药物.
- 了解ECMO电路中的药物行为对于有效的患者治疗至关重要.
研究的目的:
- 评估氧化器对新生儿/儿科 (1/4英寸) 和青少年/成年人 (3/8英寸) ECMO电路内雷梅西维尔 (RDV) 降解的影响.
- 为了量化ECMO电路中的RDV损耗,带有和没有Quadrox-i氧化器.
主要方法:
- 模拟闭环ECMO电路 (1/4英寸和3/8英寸) 用和没有Quadrox-i氧化器准备.
- 血液预制电路用RDV进行剂量注射,并在24小时内在氧化器前后测量度.
- 在玻璃瓶中的对照样本评估了自发的RDV降解.
主要成果:
- 在带有氧化器的电路中观察到显著的RDV损耗 (35%-60%在1/4英寸,60%-70%在3/8英寸).
- 没有氧化器的电路也显示了RDV损失 (5%-20%在1/4英寸,60%-70%在3/8英寸).
- 在较大的3/8英寸电路中,与1/4英寸电路相比,在较大的3/8英寸电路中注意到了更大的RDV损失.
结论:
- 雷梅西维尔 (RDV) 在ECMO电路内丢失,其程度受电路大小和潜在的氧化器的影响.
- 初步发现表明,在接受ECMO的患者中,RDV剂量可能需要调整.
- 需要对单剂和多剂量进行进一步的研究,以确认这些观察结果并指导临床实践.
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