在妊娠糖尿病中量化胎儿心脏健康:使用胎儿心脏量化技术的新方法
Pengjie Zhang1, Xinghui Fu2, Lijuan Zhao1
1Department of Ultrasound, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Frontiers in pharmacology
|June 12, 2024
概括
孕期糖尿病 (GDM) 影响胎儿的心脏功能,在怀孕后期显示右心室性能下降. 胎儿心脏量化 (胎儿HQ) 有助于评估这些与GDM相关的变化.
科学领域:
- 心脏病学 心脏病学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 医疗成像医学成像
背景情况:
- 孕期糖尿病 (GDM) 对胎儿发育构成风险.
- 在GDM怀孕中评估胎儿心脏功能对于早期干预至关重要.
- 线粒体动力学和心脏结构/功能需要进一步研究GDM胎儿.
研究的目的:
- 评估GDM对胎儿心脏结构和功能的影响.
- 使用胎儿心脏量化 (胎儿HQ) 进行综合分析.
- 专注于受GDM影响的胎儿的线粒体动力学.
主要方法:
- 通过使用胎儿HQ和斑点跟踪分析了180个胎儿 (妊娠24-40周).
- 测量了心声学参数,包括GLS,FAC和GSI.
- 胎儿根据GDM状态和妊娠期 (24-28周对28-40周) 进行分组.
主要成果:
- 与28-40周的对照组相比,GDM组的右心室功能较低.
- 在GDM组显示较低的全球球体指数 (GSI) 在28-40周 (1.175对1.22).
- 在GDM组中观察到心室分数面积变化 (FAC) 和右心室全球纵向应变 (GLS) 的显著下降.
结论:
- GDM与胎儿右心室功能下降有关,特别是在怀孕晚期.
- 胎儿HQ是评估与GDM相关的胎儿心脏变化的宝贵工具.
- 对GDM胎儿的线粒体动力学的进一步研究是有必要的.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Pathophysiology of Diabetes
920
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
920


