探索作为神经病痛疼痛管理的目标的thalamus:一个综合性审查
Mariana P Pires1, Billy McBenedict1, Issra E Ahmed2
1Neurosurgery, Fluminense Federal University, Niterói, BRA.
Cureus
|June 12, 2024
概括
先进的治疗方法,如乳头切除术和深度大脑刺激 (DBS),可以暂时缓解神经病痛 (NP). 这些干预措施调节疼痛通路,但存在风险,凸显了对NP乳头功能进一步研究的需要.
科学领域:
- 神经科学是一个神经科学.
- 疼痛管理 疼痛管理
- 神经外科 神经外科
背景情况:
- 神经病痛 (NP) 是由于体感官系统受损而引起的,导致自发或引起的疼痛.
- 丘陵体在疼痛网络中发挥着至关重要的作用,影响疼痛感知的情感-动机方面.
- 了解NP中的胸膜功能对于改善治疗耐药性疼痛的管理策略至关重要.
研究的目的:
- 在NP中回顾 thalamus 在 nociceptive 信息传输中的作用.
- 讨论先进的治疗方法的有效性和安全性,如乳头切除术和对NP的深度脑刺激 (DBS).
主要方法:
- 从主要数据库 (PubMed/MEDLINE,Embase,Scopus,Web of Science) 中综合审查科学文章.
- 从最初的687人中对15个选定的文章进行了定性分析.
- 专注于在NP管理中关于thalamotomy和DBS的证据.
主要成果:
- 乳头切除术和DBS在缓解NP症状方面表现出不同程度的有效性,缓解通常是暂时的.
- 治疗后观察到疼痛感知减少,并在随访期间保持.
- 报告了与这些手术干预相关的不良事件.
结论:
- 泰拉巴切除术和DBS在治疗常规治疗抗性慢性神经病痛方面提供了暂时的好处.
- 这些先进的手术干预措施调节大脑疼痛通路,改善了一些患者的生活质量.
- 尽管有局限性和暂时效果,但这些程序为难以治愈的NP患者提供了希望.
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