第一个三个月的禁食血葡萄糖水平和发展为2型糖尿病:一项为期5年的队列研究
Esther Maor-Sagie1,2,3, Mordechai Hallak1,2,3, Gilad Twig4,5
1Department of Obstetrics and Gynecology, Hillel Yaffe Medical Center, Haifa, Israel.
第一个三个月的禁食血葡萄糖水平预测了2型糖尿病风险,甚至比妊娠糖尿病更好. 这种早期查对于识别风险妊娠至关重要,特别是在非肥胖个体中.
科学领域:
- 内分泌学 在内分泌学.
- 孕产妇健康 孕产妇健康
- 糖尿病研究 糖尿病研究
背景情况:
- 禁食葡萄糖受损 (IFG) 是一种糖尿病前状态,但其定义 (100-125 mg/dL) 不适用于怀孕.
- 第一季度禁食葡萄糖与未来2型糖尿病 (T2D) 风险之间的联系尚未得到充分证实.
- 孕期糖尿病是已知的T2D风险因素,为比较提供了一个基准.
研究的目的:
- 根据第一季度的空腹血葡萄糖 (FPG) 水平来评估T2D的进展.
- 为了比较第一季度FPG与妊娠糖尿病诊断对T2D发展的预测能力.
- 评估孕产妇肥胖对第一季度FPG和T2D进展之间的关联的影响.
主要方法:
- 对69,001名参与者的回顾性分析.
- 禁食血葡萄糖水平测量在妊娠的第一季度.
- 主要结局:产后5年内T2D发病率.
- 统计分析包括ROC-AUC,尤登指数和生存分析与调整后的危险比率 (aHR).
主要成果:
- 86.5 mg/dL的FPG切线被确定为T2D进展的预测.
- 这种FPG截止值与妊娠糖尿病诊断相比,显示出更高的预测性能.
- 对T2D的预测能力在被孕产妇肥胖分层时得到了增强,特别是在非肥胖患者中.
结论:
- 第一季度FPG水平升高与T2D进展有显著的关联,与妊娠糖尿病风险相比或超过.
- 第一季度FPG是一个有价值的查工具,用于识别有未来T2D风险的怀孕.
- 第一季度FPG对T2D进展的影响在非肥胖女性中更为明显.
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