雄辩皮层的结构变化是感觉运动区域质瘤的次要原因
Yuhao Guo1,2, Hongbo Bao2,3, Zhishuo Wei4
1Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Human brain mapping
|June 12, 2024
概括
大脑结构重组发生在质瘤患者身上,特别是在感觉运动区域. 减弱的强度与特定大脑区域的灰质体积变化相关,表明神经可塑性.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 大脑解剖学 大脑解剖学
背景情况:
- 质瘤会导致大脑结构的变化.
- 感觉运动皮层的功能对于运动至关重要.
- 了解大脑重组是患者康复的关键.
研究的目的:
- 研究质瘤患者的感觉运动皮质结构重组.
- 在强度受损和没有受损的患者之间区分大脑变化.
- 确定受质瘤影响的特定大脑区域.
主要方法:
- 基于voxel的形态测量 (VBM) 和感兴趣区域 (ROI) 分析.
- 在感觉运动区域的灰色物质量 (GMV) 的比较.
- 分析包括受损的原发动机/感官回旋,前运动皮质,补充运动区域 (SMA) 和中间布罗德曼区域8 (BA8).
主要成果:
- 在受损右半球质瘤患者与无损和健康的对照 (HCs) 患者中增加了右中间BA8体积.
- 在左半球质瘤患者中扩大的 contralateral SMA 与无损和HCs相比.
- 观察到前运动和运动/感觉皮层的反侧灰质扩张.
- 手的强度 (MRC得分) 和对应的SMA/中等BA8体积之间的负相关性.
结论:
- 在质瘤患者的感觉运动皮质中出现了一致的结构重组.
- 对质瘤存在的适应性神经可塑性反应的证据.
- 结果为神经外科规划和康复策略提供了洞察力.
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