从慢性感染患者的射精中获得的E型肝炎病毒颗粒的传染性证明
Mathias Schemmerer1, Hans H Bock2, Jörn M Schattenberg3
1National Consultant Laboratory for HAV and HEV, Institute of Clinical Microbiology and Hygiene, University Medical Center Regensburg, Regensburg, Germany.
Journal of medical virology
|June 12, 2024
概括
肝炎E病毒 (HEV) 在慢性感染的男性的射精中具有传染性. 这一发现表明性传播的潜在风险,强调需要进一步研究HEV传播途径.
科学领域:
- 病毒学 病毒学
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
背景情况:
- 在慢性感染男性的射精中检测到肝炎E病毒 (HEV) RNA.
- 射精中的HEV颗粒的传染性仍未得到证实.
- 之前的细胞培养模型未能证明来自射精的HEV感染性.
研究的目的:
- 为了研究在射精中存在的HEV颗粒的传染性.
- 为了确定射精中的HEV是否存在性传播的风险.
主要方法:
- 使用一种优化的HEV细胞培养系统,使用过多的PLC/PRF/5细胞.
- 与血清相比,分析了射精中的HEV RNA度.
- 在细胞培养中评估了HEV复制和感染力.
主要成果:
- 首次证明了射精中的HEV颗粒具有传染性.
- 在细胞培养中达到高病毒载荷 (1e9 HEV RNA副本/毫升).
- 与患者血清相比,在射精中观察到不同的HEV RNA度.
结论:
- 阳性射精含有传染性病毒颗粒.
- 阳性射精带来了性传播的潜在风险.
- 需要进一步的研究来阐明HEV传输动态.
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