在成年人中改善口腔健康与X相关的低度血症治疗布罗苏马布治疗的成年人
Agathe Hervé1, Margaux Gadion1, Julia Herrou2
1UFR Odontologie, Université Paris Cité and AP-HP, Reference Center for Rare Diseases of the Calcium and Phosphate Metabolism, OSCAR Network, FHU DDS-net, ERN BOND, Department of Dental Medicine, Bretonneau Hospital, 75018 Paris, France.
The Journal of clinical endocrinology and metabolism
|June 12, 2024
概括
布罗苏马布显著减少了X链接低血症 (XLH) 的成年人内感染,与传统治疗或不治疗相比,改善了口腔健康. 这一发现突显了burosumab的重要意义.
科学领域:
- 遗传学和罕见疾病.
- 口腔卫生和牙科 牙科
- 药理学和治疗学 药理学和治疗学
背景情况:
- 与X相关的低酸血症 (XLH) 是一种罕见的遗传性骨疾病,具有口腔表现,包括自发的牙感染.
- 目前的XLH治疗包括常规疗法 (CT) 和布罗苏马布,一种针对纤维细胞生长因子23的抗体.
- 布罗苏马布对成年人口腔健康的影响,特别是感染的影响,在很大程度上仍未被描述.
研究的目的:
- 根据治疗方式,比较成人XLH患者的口腔健康结果和内牙感染发病率.
- 评估没有治疗,常规治疗 (CT) 和布罗苏马布在XLH口腔健康管理中的有效性.
主要方法:
- 对44名成年XLH患者的口腔健康数据的回顾性分析,包括至少六个月的牙科监测.
- 治疗方式的比较:没有治疗,常规治疗 (CT) 和burosumab.
- 评估口腔健康指标,包括缺失的/内牙治疗的牙和牙周病发病率.
主要成果:
- 口腔健康状况与在XLH治疗中度过的成年寿命相相关.
- 与没有治疗期间相比,布罗苏马布治疗显示牙感染减少了86.4% (P < .0001).
- 布罗苏马布治疗显示,与未治疗期间 (0.09 个感染/月,P < .01) 相比,与感染发病率降低 (0.006 个感染/月) 有着强烈的关联.
结论:
- 接受布罗苏马布治疗的成人XLH患者在牙科随访期间出现的内牙感染较少.
- 布罗苏马布在减少内牙感染方面似乎比常规治疗或不治疗在成人XLH患者中更有效.
- 这些发现表明,布罗苏马布通过降低成人XLH感染风险,对口腔健康产生积极影响.
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