儿童尿路感染是由家禽相关的大肠杆菌引起的
Maliha Aziz1,2, Gregg S Davis1,2, Daniel E Park1,2
1Department of Environmental and Occupational Health, Antibiotic Resistance Action Center, George Washington University, Washington, DC, USA.
Microbiology spectrum
|June 12, 2024
概括
一项研究发现,华盛顿特区19%的儿科泌尿道感染 (UTI) 是由食物传播的动物性大肠杆菌菌株引起的,可能来自受污染的家禽肉. 这凸显了食品动物对儿童的重大公共卫生风险.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 流行病学 流行病学
背景情况:
- 大肠杆菌 (E. coli) 是导致儿童和成人尿路感染的主要原因.
- 胃肠道是泌尿病原菌大肠杆菌的主要储存库,零售肉类被确定为潜在的暴露来源.
- 儿童尿道感染对公共卫生造成重大负担,并可能导致长期健康后果.
研究的目的:
- 估计华盛顿特区地区由食源性动物性大肠杆菌菌株引起的儿科尿路感染的比例.
- 为了确定与儿科尿道感染和零售家禽分离物相关的特定大肠杆菌序列类型.
- 评估零售家禽肉作为动物性大肠杆菌向儿童传播的载体的作用.
主要方法:
- 从小儿尿样和零售家禽中分离的大肠杆菌单元的全基因组测序和核心基因组遗传学分析.
- 应用贝叶斯隐性类模型,结合移动遗传元素来预测孤立宿主起源.
- 从华盛顿特区 (2013-2014) 的零售商处收集儿童 (2个月17岁) 和家禽的大肠杆菌尿液分离物 (2013-2014).
主要成果:
- 五种序列类型 (ST10,ST38,ST69,ST117,ST131) 在儿科尿液和零售家禽大肠杆菌分离物中都是常见的.
- 贝叶斯模型估计,19% (10/52) 的研究的儿科尿路感染是由食物传播的动物性大肠杆菌菌株引起的.
- 数据表明,零售家禽肉是儿童暴露于能够引起尿路感染的动物性大肠杆菌的重要潜在来源.
结论:
- 华盛顿特区儿童尿路感染的很大一部分可能来自食用动物,特别是通过受污染的家禽肉传播.
- 识别高风险的大肠杆菌菌株及其储存库可以为减少儿科人口中尿路感染负担的干预措施提供信息.
- 针对性干预,如家禽疫苗接种,可能会降低食物动物中的大肠杆菌殖民,减少肉类污染,降低儿科感染.
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