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通过非侵入性方法诊断胆固醇瘤,使用呼气中的挥发性有机化合物:试点研究

Richard E Evenhuis¹, Ibtissam Acem¹, Veroniek M van Praag¹

¹Department of Orthopaedic Surgery, Leiden University Medical Center, Leiden, The Netherlands.

Future oncology (London, England)

|June 12, 2024

概括

电子鼻子 (aeoNose) 显示出有限的能力来诊断来自呼吸中的挥发性有机化合物的软骨肉瘤. 在临床使用之前需要进一步的研究,尽管它可能有助于复杂病例的MRI.

科学领域:

在瘤学瘤学.
生物标志物生物标志物
医学诊断医学诊断医学诊断

背景情况:

软骨肉瘤的诊断依赖于像MRI这样的成像.
需要用于冠状肉瘤的非侵入性生物标志物.
呼吸中的挥发性有机化合物 (VOC) 是潜在的生物标志物.

研究的目的:

评估电子鼻子 (aeoNose) 对冠状腺癌的诊断能力.
为了区分健康人群,冠状腺癌患者和患有良性病变的人群,使用呼吸VOCs.
评估aeoNose作为潜在的诊断生物标记物的性能.

主要方法:

探索性试点研究涉及57名参与者 (25名健康人,24名软骨肉瘤,8名良性病变).
使用电子鼻子 (aeoNose) 在呼出的呼吸中分析挥发性有机化合物概况.
使用人工神经网络对样品进行分类.

主要成果:

鼻模型实现了75%的灵敏度和65%的特异性.
该模型的曲线下的面积 (AUC) 为0.66.
电子鼻子没有表现出足够的准确性来进行独立的软骨肉瘤诊断.

结论:

目前的证据不支持对AEoNose进行常规使用,以诊断冠状动脉瘤.
aeoNose可以作为MRI的辅助工具,用于模两可的软骨肉瘤病例.
需要进一步验证,以确定呼吸VOC分析对冠状动脉瘤的临床实用性.

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