Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

415
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
415
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

55
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
55
Toxic Reactions: Overview01:26

Toxic Reactions: Overview

969
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
969
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

120
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
120

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

<i>GRIN2B</i>-related neurodevelopmental disorder: current understanding of pathophysiological mechanisms.

Frontiers in synaptic neuroscience·2023
Same author

Corrigendum: An Autism-Associated <i>de novo</i> Mutation in GluN2B Destabilizes Growing Dendrites by Promoting Retraction and Pruning.

Frontiers in cellular neuroscience·2022
Same author

An Autism-Associated <i>de novo</i> Mutation in GluN2B Destabilizes Growing Dendrites by Promoting Retraction and Pruning.

Frontiers in cellular neuroscience·2021
Same author

Effect of extracellular vesicles from S. aureus-challenged human neutrophils on macrophages.

Journal of leukocyte biology·2020
Same author

Acute neurotoxicant exposure induces hyperexcitability in mouse lumbar spinal motor neurons.

Journal of neurophysiology·2020
Same author

Spatio-temporal dynamics of neocortical presynaptic terminal development using multi-photon imaging of the corpus callosum in vivo.

Scientific reports·2019

相关实验视频

Updated: Jun 24, 2025

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

18.7K

前额叶皮层网络功能障碍是由于急性神经毒剂暴露导致的.

Michael P Sceniak1, Shasta L Sabo1

  • 1Department of Biology, Central Michigan University, Mount Pleasant, Michigan, United States.

Journal of neurophysiology
|June 12, 2024
PubMed
概括

甲基 (MeHg) 暴露会导致前额叶皮层 (PFC) 过度兴奋,因为它会破坏刺激-抑制平衡. 这种神经毒剂是神经毒剂.

科学领域:

  • 神经科学是一个神经科学.
  • 毒理学 毒理学 毒理学
  • 神经退行性疾病 神经退行性疾病

背景情况:

  • 前额叶皮层 (PFC) 功能障碍与认知缺陷和前性疾病 (FTD) 有关.
  • PFC神经元容易受到刺激毒性和环境毒素的影响,这些是潜在的FTD贡献者.
  • 环境神经毒剂对PFC功能的影响仍未得到充分研究.

研究的目的:

  • 为了研究甲基 (MeHg) 诱导中部前额叶皮层 (mPFC) 神经元中的过度兴奋的能力.
  • 阐明MeHg诱导的mPFC功能障碍背后的机制.
  • 评估MeHg对FTD病原体的潜在贡献.

主要方法:

  • 使用全细胞补丁记录来评估mPFC金字塔神经元活动.
  • 对甲基 (MeHg) 进行了急性暴露.
  • 分析了刺激性和抑制性后突触电流 (EPSC和IPSC).

主要成果:

  • 暴露于MeHg (20μM) 显著增加了mPFC刺激性,因为它改变了刺激-抑制 (E-I) 平衡.
  • 无论是EPSC和IPSC费用都增加了,EPSC频率提高,并减少了对脉压抑.
  • 在自发的IPSC中,MeHg诱导了时间同步,增加了内在的神经元刺激能力和发射速度.
关键词:
在EPSC中,EPSC的领导人.谷氨酸酸盐的使用方法甲基是一种.前额叶皮层前额叶皮层.突触突触是突触的组成部分.

更多相关视频

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.1K
An Alternative Approach to Study Primary Events in Neurodegeneration Using Ex Vivo Rat Brain Slices
07:57

An Alternative Approach to Study Primary Events in Neurodegeneration Using Ex Vivo Rat Brain Slices

Published on: April 11, 2018

6.9K

相关实验视频

Last Updated: Jun 24, 2025

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

18.7K
Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.1K
An Alternative Approach to Study Primary Events in Neurodegeneration Using Ex Vivo Rat Brain Slices
07:57

An Alternative Approach to Study Primary Events in Neurodegeneration Using Ex Vivo Rat Brain Slices

Published on: April 11, 2018

6.9K

结论:

  • 甲基会诱导mPFC神经元的过度兴奋,破坏E-I平衡和抑制网络功能.
  • 这些发现表明,MeHg等环境神经毒剂可能导致FTD中所见的认知和情绪缺陷的机制.
  • MeHg对mPFC电路的影响突显了它在神经退行性疾病病因学中的潜在作用.