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合成生物活跃的 cefpodoxime 和基于素的 schiff 基础金属复合物,并进行详细的生物评估

Naeem Razaq¹, Amina Asghar², Amna Mumtaz³

¹Department of Chemistry, Division of Science and Technology, University of Education, Township, Lahore, 54770, Pakistan.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine

|June 12, 2024

概括

这项研究合成了cefpodoxime Schiff基的新型金属复合物,证明了增强的抗微生物和抗炎活性. 这些绿色合成的复合物与原始药物相比,对抗性细菌具有更高的疗效.

科学领域:

药用化学医学化学
绿色化学绿色化学
协调化学协调化学

背景情况:

抗微生物药物的希夫基提供了针对耐药细菌的增强疗效的潜力.
探索新的合成路径和金属复合对于药物开发至关重要.

研究的目的:

为了合成和表征新型过渡金属复合物的一种cefpodoxime-vanillin Schiff基.
评估合成化合物的体外抗菌,抗炎和抗氧化活性.
研究这些复合物的潜力,作为改进的治疗剂.

主要方法:

谢夫基多克西姆-瓦尼林和其金属复合物的绿色合成 (Mn(II),Cu(II),Fe(II),Zn(II),Ni(II)).
使用紫外线可见,FTIR,NMR,元素分析,ICP-OES和LC-MS进行表征.
在体外评估抗菌,抗炎 (蛋白酶抑制) 和抗氧化剂 (DPPH测定) 活动.
使用补丁码头对抗GlcN-6-P合成酶的分子对接研究.

主要成果:

八面体几何学通过UV可见光谱学证实金属复合体.
与原始药物和自由配体相比,合成的金属复合物在体外表现出增强的抗菌活性.
对复合体观察到显著的抗炎和抗氧化活性.
分子对接表明复合体2b是对GlcN-6-P合成酶的强有力的抑制剂.

结论:

合成的 cefpodoxime Schiff 基础金属复合物具有卓越的生物活性.
绿色合成方法产生了有效的抗微生物和抗炎药物.
这些金属复合体代表了开发抗耐药细菌感染的新药的有希望的候选人.

关键词:

具有抗菌活性,具有抗菌活性.头类子素是什么?希夫基联结体的基础联结体瓦尼林和香是一种

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