长期多发性骨髓瘤幸存者的主要心血管事件:韩国病例对照研究 (CAREMM-2105研究)
Jeonghoon Ha1, Suein Choi2,3, Seulji Moon2,3
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea.
Clinical and experimental medicine
|June 12, 2024
概括
长期多发性骨髓瘤 (MM) 幸存者总体上表现出较低的心血管疾病 (CVD) 风险,但年轻患者需要对心血管疾病进行警监测. 早期检测和个性化干预对这一群体至关重要.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 多发性骨髓瘤 (MM) 的生存率有所改善,但幸存者的长期心血管结果尚未得到充分记录.
- 了解MM幸存者的心血管风险对于全面的癌症幸存者护理至关重要.
研究的目的:
- 为了比较长期多发性骨髓瘤 (MM) 幸存者和匹配的对照组之间的心血管疾病 (CVD) 发病率.
- 在MM幸存者群体中确定特定的风险因素和患心血管疾病风险较高的患者子组.
主要方法:
- 一项使用韩国国家医疗保险服务数据库 (2009-2020) 的回顾性病例控制研究.
- 15,402名MM患者的倾向评分与15402名基于出生年份和性别的对照进行了匹配.
- 8年随访期间心血管事件和心血管疾病风险的累积发病率的比较.
主要成果:
- 与对照人群相比,长期MM幸存者在8年后的随访期间,心血管事件的累积发病率 (12.5%与22.1%) 和整体心血管疾病风险明显较低.
- 一项为期5年的基准分析显示,MM患者心血管疾病发病率较低 (7.8%),而不是对照组 (9.8%).
- 初始MM诊断时年龄在50岁以下的患者与老年MM患者和对照人群相比,心血管疾病风险显著增加.
结论:
- 对所有长期多发性骨髓瘤幸存者来说,需要对心血管疾病进行警监测.
- 年轻的MM幸存者 (在50岁之前被诊断出来) 需要特别注意,因为他们的心血管疾病风险较高.
- 将心血管风险管理纳入MM幸存者的长期护理计划,专注于针对年轻患者的个性化干预,至关重要.
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