多基因分数和心理病理症状网络
Giulia G Piazza1, Andrea G Allegrini1,2, Thalia C Eley2
1Department of Clinical, Educational and Health Psychology, University College London, London, United Kingdom.
JAMA psychiatry
|June 12, 2024
概括
多基因评分与精神疾病中的特定症状子集有关,而不是所有症状. 这种症状层面的分析提供了一个更清晰的看法,对遗传影响的精神病理学和并发症.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 发展心理学 发展心理学
背景情况:
- 精神病特征研究经常使用一种疾病级别的方法,假设症状均.
- 症状异质性是常见的,在一个疾病诊断下有多种症状组合.
- 专注于个体症状可以阐明多基因风险在精神病理学中的作用.
研究的目的:
- 调查多基因分数是否与所有精神疾病症状或特定子集相关.
- 通过特定的症状集来确定多基因得分是否与共患性表型有关.
- 探索儿童精神病理学中多基因风险的症状水平关联.
主要方法:
- 对两个基于人口的队列的横截面分析:阿文长度研究父母和孩子 (ALSPAC) 和双胞胎早期发育研究 (TEDS).
- 包括具有遗传数据的参与者和11岁儿童症状的母亲报告,使用短情绪和感觉问卷和强度和困难问卷.
- 构建了个体症状和抑郁症,焦虑症,ADHD,BMI和教育成就的多基因分数的心理网络.
主要成果:
- 多基因得分优先与受限制的症状子集相关,间接与远端精神病理症状联系在一起.
- 精神病学多基因评分显示了特定的跨疾病症状关联.
- 非精神病学多基因评分 (例如,BMI) 与疾病中的各种症状相关,这表明在并发症中发挥了作用.
结论:
- 疾病层面的遗传关联可能会掩盖重要的症状层面的异质性.
- 症状层面的方法提供了对多基因风险对精神病理学影响的更细致的理解.
- 这项研究支持对对心理健康和并发症的遗传影响进行细分检查.
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