运动的血蛋白质学 血压和事件高血压
Prashant Rao1,2, Michelle J Keyes2, Michael Y Mi1,2
1Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
JAMA cardiology
|June 12, 2024
概括
运动血压 (EBP) 与未来的高血压和心血管疾病 (CVD) 有关. 这项研究确定了TGFBR3作为与EBP相关的蛋白质标记物,可能提供对高血压和心血管疾病事件的保护.
科学领域:
- 心血管生理学心血管生理学
- 蛋白质组学是指蛋白质组学.
- 高血压研究 高血压研究
背景情况:
- 运动血压 (EBP) 是未来高血压和心血管疾病 (CVD) 的预测因素.
- 了解EBP的生物化学基础可能会揭示高血压的新生物标志物.
- 目前的研究缺乏对EBP的全面蛋白质组分析.
研究的目的:
- 识别与运动血压 (EBP) 相关的血蛋白标记物.
- 调查已识别的蛋白质与发生高血压的关联.
- 探索这些蛋白质与心血管结果之间的潜在因果关系.
主要方法:
- 在681名来自HERITAGE家庭研究的健康参与者中测试了4977种血蛋白.
- 评估了静止血蛋白水平与静止血压 (BP) 和EBP之间的关联.
- 在弗雷明汉心脏研究,杰克逊心脏研究和动脉样硬化多民族研究中验证了蛋白质与发生高血压的关联.
- 利用cis-蛋白质定量定位门德尔随机化 (cis-MR) 来评估约70万个人的因果关系.
主要成果:
- 蛋白质基因分析确定了34种与EBP相关的蛋白质,仅仅从静止BP中就不清楚.
- 转化生长因子β受体3 (TGFBR3) 显示了与运动系统性血压的最强的反向关联.
- 在三个验证队列中,TGFBR3与发生高血压相反相关.
- 基因预测的TGFBR3水平与较低的缩血压,高血压和心血管疾病事件风险降低有关.
结论:
- 对EBP的血蛋白质定型确定了TGFBR3作为一种新型蛋白质标记物.
- TGFBR3可能对高血压和长期心血管疾病起着保护作用.
- 这些发现突出了TGFBR3作为潜在的治疗标和高血压和心血管疾病风险的生物标志物.
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
77
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
77
01:17Hormonal Regulation of Blood Pressure
2.6K
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
2.6K
01:18Hypertension and Regulation of Blood Pressure
2.1K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
2.1K
01:20Exercise and Cardiovascular Response
784
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
784
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
137
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
137
01:30Blood Pressure
1.1K
Blood pressure (BP) is the pressure or force of blood exerted on the artery's walls as it circulates through the body. It is essential for maintaining blood flow throughout the body.
The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the...
The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the...
1.1K