发生率和治疗模式在患有状状的患者中
Natalia Pelet Del Toro1, Andrew Strunk1, Amit Garg1,2
1Department of Dermatology, Northwell Health, New Hyde Park, New York.
JAMA dermatology
|June 12, 2024
概括
在美国,每10万名成年人中,有13.4人患有状 (Lichen planopilaris,LPP),主要是女性. 大多数患者接受皮质类固醇等治疗,但许多人会切换或结合疗法,表明需要优化治疗策略.
科学领域:
- 皮肤病学 皮肤病学
- 流行病学 流行病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 平 (LPP) 是一种痕性脱发症,导致永久性脱发,疼痛和,关于其特征和治疗的数据有限.
- 由于对疾病病理生理学和治疗疗效的不完全理解,有效管理LPP具有挑战性.
- 需要了解美国成年人群中LPP的患病率和常见的治疗方法.
研究的目的:
- 为了确定美国成年人中状 (LPP) 的患病率.
- 描述皮肤病医生在诊断后第一年内为LPP开具的治疗模式.
- 分析LPP患者的治疗延续,切换和组合疗法.
主要方法:
- 一项利用Explorys数据库进行的横截面研究分析了2017-2019年间美国成年LPP诊断的流行率.
- 评估了2016-2020年间诊断的LPP患者的治疗模式,这些患者在一年内遇到了皮肤科医生.
- 数据分析发生于2023年1月至2023年4月,检查了人口群体和治疗方式的流行率.
主要成果:
- 标准化的LPP患病率为每10万美国成年人中13.4人,诊断患者中有92.1%为女性.
- 内溶性皮质类固醇 (37.3%) 和局部皮质类固醇 (34.5%) 是最常见的初始治疗方法.
- 超过三分之一的患者继续治疗超过一年,并且很大一部分患者转换或结合疗法.
结论:
- 这项研究提供了关键的数据,关于在美国的Lichen planopilaris的流行率和皮肤病治疗模式.
- 治疗修改 (交换和组合) 的高率表明有效管理LPP的持续挑战.
- 进一步研究优化LPP的药物选择和治疗序列是有必要的,以改善临床结果.
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