加速计衍生睡眠,体力活动和昼夜节律领域的整合建模与当前或缓解的大型抑郁症
Sun Jung Kang1, Andrew Leroux2, Wei Guo1
1Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, Maryland.
JAMA psychiatry
|June 12, 2024
概括
加速度计揭示了在重大抑郁症 (MDD) 中对睡眠,活动和昼夜节律的联合影响. 减弱的昼夜节律可能是MDD的特征标志物.
科学领域:
- 精神病学和行为科学
- 生物医学工程 生物医学工程
- 时间生物学 时间生物学
背景情况:
- 加速度计客观地测量睡眠,身体活动和情绪障碍中的昼夜节律.
- 之前的研究经常孤立地检查这些领域,忽视了相互关联.
- 很少有研究在主要抑郁障碍 (MDD) 中区分特征和状态加速度计概况.
研究的目的:
- 用联合和个体变化解释 (JIVE) 方法识别加速计衍生的睡眠,身体活动和昼夜节律的关节和个体组件.
- 检查这些联合和单独组件与当前和汇款的MDD之间的关联.
- 探索加速计作为抑郁症亚型的生物标志物的潜力.
主要方法:
- 一项横截面研究分析了2317名成年人 (瑞士洛桑) 的加速度计数据.
- 联合和个体变化解释 (JIVE) 方法应用于28个加速度计特征,持续了14天.
- 对共变量调整后的物流回归检查了与当前和转账的MDD的关联.
主要成果:
- 在睡眠,体力活动和昼夜节律领域,JIVE确定了3个联合和6个单独的组件.
- 联合组件解释了这些领域的大量变化 (54.579.5%).
- 当前和缓解的MDD都与反映身体活动强度,昼夜幅度和睡眠/活动时间的关节组件有关;MDD显示昼夜节律较弱.
结论:
- 一种新的多式减维技术突出了身体活动,昼夜节律和睡眠/活动时间对MDD的联合影响.
- 减弱的昼夜节律可能作为MDD的特征标志物.
- 加速度计显示为抑郁症亚型的生物标志物具有前途,强调24小时睡眠-觉醒周期的重要性.
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