基于双功能的远程形形块共聚物的抗菌水凝
Natalia Sanz Del Olmo1, Noemi Molina1, Yanmiao Fan1
1Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, Teknikringen 56-68, 100 44 Stockholm, Sweden.
Journal of the American Chemical Society
|June 12, 2024
概括
提供可调节的抗菌活性, 解决对抗生素替代品的迫切需要. 这些多功能材料可以快速治愈和功能化用于广泛的病原体控制.
科学领域:
- 生物材料科学
- 聚合物化学
- 传染病研究
背景情况:
- 抗生素耐药性病原体是一个重大的全球健康威胁.
- 迫切需要新型抗菌材料来取代传统的抗生素.
- 水凝为开发先进的抗菌溶液提供了一个有前途的平台.
研究的目的:
- 开发下一代有抗菌活性和高通用性的阴离体水凝.
- 使用烯点击化学 (TEC) 在水性条件下快速形成水凝.
- 通过修改水凝成分和交联密度来探索可调节的抗菌性能.
主要方法:
- 基于远程聚的树突-线性-树突 (DLDs) 块共聚物的合成与基和基.
- 通过TEC与醇功能化聚乙烯糖醇 (PEG) 交叉链接DLD.
- 制造具有不同交叉连接密度和功能组的两组和三组水凝网络.
- 对抗格拉姆阴性和格拉姆阳性细菌的抗菌活性评估.
- 机械性能 (储存模块) 和稳定性的评估 (膨胀实验).
主要成果:
- 使用TEC在水性条件下实现了化的快速固化 (<20秒).
- 观察到可调节的抗菌活性,非静态测量水凝针对格兰阴性细菌.
- 使用囊胺衍生物功能化的三元网络表现出更广泛的活性,包括对阳性细菌的活性.
- 水凝表现出多功能机械性能 (2707024 Pa) 和稳定性 (156天).
- 与皮肤细胞具有良好的生物相容性,并对各种表面具有强烈的粘附性.
结论:
- 开发的阴离子水凝为抗生素耐药细菌提供了多功能和可调节的平台.
- 在水性环境中,TEC可快速,按需形成水凝.
- 功能化策略允许量身定制的抗菌谱和材料特性.
- 这些水凝代表了各种生物医学应用中常规抗生素的有希望的替代品.
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