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Updated: Jun 24, 2025

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从BNST到PNOCARC神经元的GABAergic消抑制促进了HFD诱导的过

Tamara Sotelo-Hitschfeld1, Marielle Minère2, Paul Klemm1

  • 1Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany; Policlinic for Endocrinology, Diabetes, and Preventive Medicine (PEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany.

Cell reports
|June 12, 2024
PubMed
概括

高脂肪饮食激活了弧形核 (ARC) 中的前前诺西丁 (PNOC) 神经元,通过GABA抑制了食欲调节的前前梅拉诺科丁 (POMC) 神经元. 这会重新连接神经回路,导致过度饮食和肥胖.

关键词:
CP:新陈代谢过程中的新陈代谢.科普:神经科学是什么意思

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