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Updated: Jun 24, 2025

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一个α-格酸盐构造开关控制人类FTO蛋白的铁可访问性,激活性和基质选择

Daniel Burns1, Balabhadra Khatiwada2, Aayushi Singh2

  • 1Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011.

Proceedings of the National Academy of Sciences of the United States of America
|June 12, 2024
PubMed
概括

脂肪质量和与肥胖相关的 (FTO) 蛋白质通过激活α-谷酸盐来去甲基化核酸. 核酸结合稳定了构造,使铁催化剂暴露在氧气中,提高了脱甲基化效率.

关键词:
这就是Alkb二氧化基酶的作用.这是一种N6-甲基氨酸.这是NMR的NMR.液态染色学 质谱学 质谱学分子动力学模拟,分子动力学模拟

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