塔拉佐帕里布在患有BRCA1/BRCA2突变的固体瘤患者中:来自向药物和分析利用注册表研究的结果
Gordan Srkalovic1,2, Michael Rothe3, Pam K Mangat3
1Herbert-Herman Cancer Center, Lansing, MI.
JCO precision oncology
|June 12, 2024
概括
塔拉佐帕里布在患有 BRCA1/2 突变的高级固体瘤的患者中显示出显著的抗瘤活性. 这种向治疗在各种癌症类型中表现出有效性,为患有特定遗传变异的患者提供了新的希望.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 临床试验 临床试验
背景情况:
- 针对性代理和分析利用注册表研究 (TAPUR) 是一个第二阶段的篮子试验.
- 它评估已知的药物向基因组改变的晚期癌症的向药物.
- 本报告重点关注BRCA1/2突变患者的talazoparib.
研究的目的:
- 评估talazoparib在患有晚期固体瘤和BRCA1/2突变的患者中的抗瘤活性.
- 确定疾病控制 (DC) 率,定义为客观反应 (OR) 或至少16周 (SD16+) 的稳定疾病 (SD).
主要方法:
- 招募了28名患有各种固体瘤和BRCA1/2突变的患者队列.
- 患者患有晚期疾病,可测量的病变和ECOG性能状态0-2.
- 主要终点是DC,使用单面精确二项式测试进行评估.
主要成果:
- 在可评估患者中,Talazoparib 实现了 57% 的 DC 率和 36% 的 OR 率.
- 在多种瘤类型中观察到显著的抗瘤活性,包括乳腺,卵巢和肺癌.
- 13名患者经历了3-5级不良事件,符合talazoparib已知的安全性.
结论:
- 塔拉佐帕里布在患有晚期固体瘤和BRCA1/2突变的患者中表现出显著的抗瘤活性.
- 这包括在癌症类型中的疗效,目前尚未获得FDA批准的多ADP-ribose聚合酶 (PARP) 抑制剂治疗.
- 塔拉佐帕里布对这种患者群体来说是一个有前途的治疗选择.
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