在人类的背侧前额皮层中绘制皮层刺激性的地图.
Juha Gogulski1, Christopher C Cline2, Jessica M Ross3
1Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA; Department of Clinical Neurophysiology, HUS Diagnostic Center, Clinical Neurosciences, Helsinki University Hospital and University of Helsinki, Helsinki, FI-00029 HUS, Finland.
概括
通过TMS-脑电图 (TMS-EEG) 将跨磁刺激 (TMS) 映射到背侧前额皮质 (dlPFC),可以发现最佳的刺激目标. 个性化向可能进一步增强早期的TMS唤起潜力 (TEP) 治疗抑郁症.
科学领域:
- 神经科学是一个神经科学.
- 神经调节是一种神经调节.
- 大脑刺激 大脑刺激
背景情况:
- 跨磁刺激 (TMS) 通过准背侧前额皮质 (dlPFC) 有效治疗抑郁症.
- 对于TMS的神经效应,特别是早期TMS唤起的潜力 (TEP),我们仍然不完全理解.
- 与脑电图 (TMS-EEG) 相结合的TMS提供了一种探测这些神经反应的方法,但需要仔细地绘制图表,以考虑亚区域变化和肌肉人工物.
研究的目的:
- 通过dlPFC在解剖学和时间上表征早期的TEP (EL-TEPs,20-50毫秒) 和肌肉人工物 (<20毫秒).
- 调查TMS位置和线圈角度对EL-TEP和潜在的肌肉人工物混的影响.
- 确定最佳的团体级和个性化的TMS目标,以最大限度地提高dlPFC中的EL-TEP.
主要方法:
- 单脉冲TMS被应用于16名健康参与者的6个dlPFC目标.
- 对于每个目标,EEG响应被记录在两个不同的线圈角度.
- 分析的重点是早期的TEP (EL-TEPs) 和相关的肌肉人工物.
主要成果:
- 刺激位置对EL-TEP产生了重大影响,后部和中部dlPFC目标产生了更大的反应.
- 具有较高EL-TEP振幅的区域显示肌肉人工物较少,这表明存在空间关系.
- 一个最佳的群体级目标将EL-TEP响应增加了102%,个性化准可能会提供另外36%的增强.
结论:
- 后中部dlPFC区域允许以最小的肌肉相关工件进行EL-TEP评估.
- 确定一个最佳的团体级TMS目标可以提高EL-TEP的规模.
- 个性化向为TMS-EEG研究和抑郁症治疗方案提供了进一步的优化潜力.
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