改变心脏自主功能与精神分裂症中的自我障碍有关
Karl Erik Sandsten1, Magnus T Jensen2, Ditte Saebye3
1Department of Neuroscience, University of Copenhagen, Denmark.
精神分裂症患者显示,自我障碍与自主神经系统功能障碍之间存在联系. 这种功能障碍,以升高的静止心率和降低心率可变性来表示,可能是精神分裂症的脆弱性特征.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 心脏病学 心脏病学
背景情况:
- 自主神经系统 (ANS) 功能障碍,以升高的静止心率 (RHR) 和降低心率可变性 (HRV) 为标志,在精神分裂症 (SCZ) 中观察到.
- 这种ANS功能障碍可能会在临床诊断之前出现,这表明它可能在精神分裂症的脆弱性中起作用.
研究的目的:
- 调查最近出现的精神分裂症中自我障碍 (SD) 和心脏自主功能之间的关联.
- 为了确定SDs是否通过EASE手册测量,与SCZ患者的RHR和HRV参数相关.
主要方法:
- 一项病例控制研究涉及35名近期出现的SCZ患者和33名健康对照 (HC).
- 电心电图 (ECG) 的记录被用来测量RHR和HRV (RMSSD,SDNN,HF/LF比率).
- 皮尔森相关性和调整的线性回归模型分析了EASE分数 (SDs) 和心脏自主性措施之间的关系.
主要成果:
- 在SD和RHR (r=0.463;p=0.005) 之间发现了中度的积极关联.
- 在SD和RMSSD之间观察到中度的负相关性 (r=-0.440;p=0.008).
- 在SCZ组中,SD解释了RHR变异的22%和RMSSD变异的19%. SDs也与LF/HF比率相关 (r=0.434;p=0.009).
结论:
- 这项研究提供了证据,将自我障碍与精神分裂症谱系障碍的易感性特征联系起来.
- 改变心脏自主功能,特别是更高的RHR和更低的HRV,与最近出现的精神分裂症的自我障碍有关.
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