在新发型2型糖尿病和糖尿病前期患者中,循环阿斯素度
Hongcui Diao1, Xiujie Fan2, Zhe Li3
1Department of Endocrinology, Jinan Central Hospital, Shandong University, Jinan, China; Department of Endocrinology, Central Hospital Affiliated to Shandong First Medical University, Jinan, China; Department of Endocrine and Metabolic Disease, Medical Integration and Practice Center, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Diabetes research and clinical practice
|June 12, 2024
概括
血清阿斯素水平升高与2型糖尿病 (T2DM) 和糖尿病前期有关. 这一发现表明,阿斯素可能表明早期的葡萄糖平衡障碍.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 糖尿病研究 糖尿病研究
背景情况:
- 关于阿斯素在2型糖尿病 (T2DM) 中的作用存在不同的发现.
- 有限的研究已经探讨了阿斯素对糖尿病前期疾病的影响,例如葡萄糖调节受损 (IGR).
研究的目的:
- 调查血清阿斯素水平与T2DM存在之间的关联.
- 评估阿斯素作为早期葡萄糖代谢异常的生物标志物的潜力,包括IGR和T2DM.
主要方法:
- 一项观察性研究涉及252名成年人,分为正常葡萄糖耐受性 (NGT),IGR和T2DM组.
- 使用酶相关免疫吸收试验 (ELISA) 量化血清阿斯素水平.
- 参与者接受了人体测量和生化标志物的评估.
主要成果:
- 新诊断T2DM患者的血清阿斯素水平显著升高,与NGT组相比,IGR组的血清阿斯素水平略有增加.
- 在asprosin四分位数中观察到IGR+T2DM患者比例的逐渐增加,这表明存在潜在的风险关联.
- 接收器操作特征 (ROC) 曲线分析显示,在识别IGR+T2DM时,阿斯素的曲线下面面积 (AUC) 为0.853,值为4.95ng/ml.
结论:
- 患有糖尿病前期 (IGR) 和新诊断T2DM的个人表现出血清阿斯素水平升高.
- 增加的阿斯素度与早期的葡萄糖平衡中断有关.
- 阿斯素可以作为一种潜在的生物标志物,用于识别有T2DM风险或T2DM早期阶段的个体.
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