在美国成年人中,黄类药物摄入量与类风湿性关节炎之间的关联
Yan Chen1, Haoxian Tang2, Nan Luo3
1Department of Rheumatology and Immunology, The First Affiliated Hospital of Shantou University Medical College, Shantou, China; Department of Clinical Medicine, Shantou University Medical College, Shantou, China.
The Journal of nutritional biochemistry
|June 12, 2024
概括
美国成年人摄入较高的总体黄和黄与风湿性关节炎 (RA) 的风险降低有关. 这种饮食因素可能有助于预防RA的发病和进展.
科学领域:
- 营养科学 营养科学
- 流行病学 流行病学
- 类风湿病学 类风湿病学
背景情况:
- 基础研究表明,在动物模型中,黄素具有与类风湿性关节炎 (RA) 相关的抗炎性质.
- 目前,将黄类药物摄入量与人类RA患病率联系起来的临床数据有限.
- 饮食干预对于预防RA发病和进展至关重要.
研究的目的:
- 调查总黄和子类摄入量与美国成年人中RA患病率之间的关联.
- 确定特定的黄类子类是否有助于降低RA风险.
- 提供关于食类黄素在RA预防中的作用的临床证据.
主要方法:
- 从三个国家健康和营养调查 (NHANES) 周期 (2007-2008,2009-2010,2017-2018) 的数据分析.
- 包括7,419名美国成年人 (≥20岁) 与来自美国农业部饮食研究食品和营养素数据库 (FNDDS) 的黄类摄入量数据.
- 使用加权的多变量逻辑回归模型来评估黄素摄入四分位数与RA分类之间的关联,控制混因素.
主要成果:
- 总黄类药物摄入量与RA风险之间观察到显著的反向关联;较高的四分位数显示RA风险逐渐降低 (P=.03).
- 高摄入的黄类,一个黄类子类,显著与降低的RA流行率相关 (趋势:P=.02).
- 对于其他黄类子类与RA风险没有发现显著的关联.
结论:
- 在美国成年人中,全方位的黄类药物消费与患类风湿性关节炎的风险降低有关.
- 特别是flavanones,显示出对RA的保护作用.
- 这些发现强调了饮食中黄类素摄入量在RA预防策略中的重要性.
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