微调脂质体完整性以实现差异化转细胞和增强抗瘤功效

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Jiajia Su¹, Chenchen Wu¹, Jiahui Zou¹

¹Department of Pharmaceutics, China Pharmaceutical University, Jiangsu 210009, PR China.

Journal of controlled release : official journal of the Controlled Release Society

|June 12, 2024

概括

这项研究开发了一种脂质体系统 (HA-P-L_BAY),在内皮细胞的转细胞化过程中保持结构完整性. 这改善了药物输送和增强瘤抑制,为抗瘤疗法提供了一个有前途的战略.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

纳米药物旨在通过转细胞化改善瘤扩散.
在多细胞层运输过程中纳米医学的结构完整性会影响治疗的有效性.

研究的目的:

构建和评估一个脂质体系统 (HA-P-L_BAY) 来增强瘤药物输送.
微调纳米药物的结构完整性,以改善转细胞和瘤保留.

主要方法:

开发了一种充满BAY 87-2243的氨酸 (HA) 交联脂体系统,并用低分子量原氨酸 (LMWP) 进行修改.
用于体外细胞吸收,跨井检测,光共振能量转移 (FRET) 和传输电子显微镜 (TEM).
在低透性和高透性瘤模型中评估体内瘤抑制.

主要成果:

HA-P-L_BAY通过内皮细胞和ER/Golgi通路转细胞的HA-P-L_BAY被证明是活跃的,卡韦林和HSPG介导的内细胞.
在转细胞化后,HA交叉连接比静电涂层更有效地保护了纳米医学完整性.
由于更好的完整性和HA降解诱导的聚合,在瘤细胞中观察到增强的保留和细胞毒性.

结论:

微调纳米载体的结构完整性对于有效的抗瘤疗法至关重要,无论转细胞形成的贡献如何.
HA-P-L_BAY系统为具有结构完整性和选择性瘤聚合的活性跨内皮细胞运输提供了一个有前途的战略,用于长时间的保留.

关键词:

活跃的跨内皮细胞运输.化学交叉连接脂质体的化学交叉连接精细调整脂质体完整性的微调.改善了跨内皮的纳米结构完整性.细胞内聚合的细胞内聚合.长时间的瘤保留时间.

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