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显微扩散系数 (ADC) 在MRI上区分视网母细胞瘤与科茨病

Wendy X Zhang¹, Joshua S Shimony², Gregg T Lueder³

¹University of Missouri School of Medicine (W.X.Z.), Columbia, Missouri, USA; Department of Ophthalmology and Visual Sciences, Washington University School of Medicine (W.X.Z., G.T.L., M.M.R.), St. Louis, Missouri, USA.

American journal of ophthalmology

|June 12, 2024

概括

通过MRI测量的明显扩散系数 (ADC) 可以帮助区分儿童的视网膜母细胞瘤与科茨病. 在科茨病中观察到较高的ADC值,有助于诊断.

科学领域:

眼科医生眼科眼科
放射学放射学是一门学科.
儿科瘤学儿科瘤学

背景情况:

考茨病和视网膜母细胞瘤在儿童中难以区分.
以前的MRI研究集中在眼睛大小和视网膜脱落等特征上,但缺乏关于明显扩散系数 (ADC) 的数据.

研究的目的:

评估来自MRI的ADC值在儿童患者中区分科茨病和视网膜母细胞瘤的有用性.
调查ADC是否可以作为一个客观的参数来帮助诊断.

主要方法:

在2018-2022年期间,对被诊断患有科茨病或视网膜母细胞瘤的18岁以下儿童进行了回顾性横截面研究.
分析了5个患有科茨病的眼睛和29个患有视网膜母细胞瘤的眼睛的MRI扫描.
使用滴眼工具测量眼内病变的平均ADC值,并使用t-test对组进行比较.

主要成果:

视网母细胞瘤的平均ADC为442 mm2/s,明显低于科茨病的1364 mm2/s (P < .001).
900 mm2/s的ADC值在区分数据集中的两个条件方面表现出很高的准确性.
证实了ADC测量的内部可靠性.

结论:

从扩散权重MRI中获得的ADC为诊断视网膜母细胞瘤和科茨病提供了潜在的客观方法.
这种定量MRI参数可以帮助临床医生确认或确立诊断,当临床特征模糊时.
为了更广泛的临床应用,可能需要在不同的MRI扫描仪和序列中进一步验证.

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