重新考虑甲状腺皮层投影的核心和矩阵分类
S Murray Sherman1, W Martin Usrey2
1Department of Neurobiology, University of Chicago, Chicago, Illinois 60637 msherman@bsd.uchicago.edu.
概括
有影响力的核心/矩阵分类的thalamocortical投射没有证据支持. 研究人员主张放弃这种模型,以更全面地了解大脑连接.
科学领域:
- 神经科学是一个神经科学.
- 大脑解剖学 大脑解剖学
- 皮层连接 皮层连接 皮层连接
背景情况:
- 1998年提出的核心/矩阵模型,根据它们的投射模式和皮质层目标,对皮层投射进行了分类.
- 核心预测是具体的和地形的,针对信息传输的中间皮质层.
- 矩阵投影是分散的,不那么地形,并准上层,调节全球功能,如兴奋.
研究的目的:
- 批判性地评估核心/矩阵分类的真实性和实用性.
- 确定当前的证据是否支持核心/矩阵模型提出的不同类别.
- 为放弃核心/矩阵分类辩论,因为它的局限性和潜在误导性.
主要方法:
- 审查和分析现有的文学在thalamocortical投影形态和功能.
- 检查支持或反驳核心和矩阵预测的独特特征的证据.
- 评估最近的假设,将核心/矩阵投射与第一阶和更高阶的胸膜继电器联系起来.
主要成果:
- 虽然一些甲状腺皮层连接符合"核心"定义,但一个独特的"矩阵"类别缺乏明确的证据,并表现出显著的形态变异.
- 核心投射和第一阶继电器,以及矩阵投射和更高阶继电器之间的提议等价性,没有得到现有数据的支持.
- 现有证据显示,在甲状腺皮层连接中存在相当大的多样性,这些连接不完全符合核心或矩阵分类.
结论:
- 核心/矩阵分类是不够的,并可能误导理解thalamocortical相互作用.
- 需要修订,更全面的分类系统的thalamocortical投影.
- 放弃核心/矩阵模型将有助于更准确地了解大脑电路和功能.
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