在重症患者中,体重指数,生物年龄和脆弱性之间的关联
1School of Veterinary & Life Sciences, Murdoch University, Perth, WA 6150, Australia; Fiona Stanley Hospital, Medical School, University of Western Australia, Perth, WA 6150, Australia; Department of Anaesthesia and Intensive Care, Prince of Wales Hospital, the Chinese University of Hong Kong, Hong Kong Special Administrative Region of China.
Obesity research & clinical practice
|June 12, 2024
概括
身体质量指数 (BMI) 与脆弱性和生物年龄有关,但只有脆弱性和生物年龄预测急性护理中的死亡率. 这可能解释了肥胖悖论.
科学领域:
- 老年学是一门学科.
- 关键护理医学 关键护理医学
- 生物统计学 生物统计学
背景情况:
- 身体质量指数 (BMI) 和急性护理环境中的患者结果之间的关联是有争议的,一些研究表明有保护作用 (肥胖悖论),而另一些研究表明结果更差.
- 这项研究调查了BMI,生物年龄和重症患者的脆弱性之间的复杂关系.
研究的目的:
- 要确定身体质量指数 (BMI) 是否与脆弱性和生物年龄有关.
- 评估BMI是否在考虑脆弱性和生物年龄后仍然是死亡率的预测指标.
主要方法:
- 一项回顾性队列研究分析了877名重症监护病房患者,提供了BMI,脆弱性和生物年龄的数据.
- 生物年龄的估计是使用基于DNA甲基化标记的Levine PhenoAge模型从九个血液测试中估计.
- 用单变量和多变量回归分析了关联,包括限制立方线来建模非线性关系.
主要成果:
- 临床脆弱性和生物年龄残留物都显示出与BMI的U形关联 (分别为p=0.003和p=0.001).
- 体重指数与医院死亡率没有显著的关系.
- 脆弱性 (p=0.015) 和生物年龄残留 (OR 1.50 每十年; p=0.031) 在调整共变量后独立预测死亡率.
结论:
- 身体质量指数 (BMI) 与脆弱性和生物年龄显著相关,以U形的方式.
- 然而,只有脆弱性和生物年龄,而不是BMI,在这个队列中独立预测死亡率.
- 这些发现可能为急性护理环境中观察到的肥胖悖论提供了部分解释.
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