在患有结核性硬化症的儿童中,手术的途径与复杂相关的
L Gauer1, S Lagarde2, M-P Valenti-Hirsch1
1Hôpitaux Universitaires de Strasbourg, Neurology Department, Strasbourg, France; Hôpitaux Universitaires de Strasbourg, Reference Centre for Rare Epilepsies (member of the ERN network EPICARE), Strasbourg, France.
Revue neurologique
|June 12, 2024
概括
手术可以在患有结核性硬化综合症的儿童中有效,即使有同时出现的疾病. 这些儿童的手术结果与其他耐药性患者群体相似.
科学领域:
- 神经学 神经学
- 儿科症 儿科症
- 结核性硬化综合体 结核性硬化综合体
背景情况:
- 手术的疗效已知在精选患有结核性硬化综合体 (TSC) 的儿童中.
- 与TSC相关的手术的患者选择和特征仍未得到充分描述.
- 这项研究详细介绍了20多年来患有TSC的儿童手术的途径.
研究的目的:
- 描述患有TSC的儿童手术的患者选择和特征.
- 分析手术结果,并将其与非手术管理进行比较.
- 确定影响这一群体外科成功的因素.
主要方法:
- 来自法国两个中心的84名患有TSC和的儿童的回顾性队列研究.
- 收集的数据包括人口统计,病史和手术程序.
- 包括注册表匹配和医疗记录审查.
主要成果:
- 19%的儿童接受了切除手术,通常在4岁之前;44%的儿童接受了立体电脑摄影.
- 在手术后1年,57%的患者实现了无,在手术后10年,43%的患者实现了无.
- 52%的非手术耐药患者没有发作;50%的手术患者减少了抗发作药物.
结论:
- 患有TSC的儿童的手术产生了与其他耐药患者群体相比较的结果.
- 诸如婴儿或发育障碍等情况并不是绝对的禁忌,但可能会降低发作自由率.
- 没有手术的患者可能会自发演变为药物敏感性.
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