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整个表达的周围血液转录组在儿科重症疟疾性贫血中

Samuel B Anyona1,2, Qiuying Cheng3, Sharley A Wasena4,5

  • 1Department of Medical Biochemistry, School of Medicine, Maseno University, Maseno, 40105, Kenya. sanyona@maseno.ac.ke.

Nature communications
|June 12, 2024
PubMed
概括

儿童严重疟疾性贫血 (SMA) 涉及免疫反应和细胞调节受损. 转录组分析揭示了被破坏的通路,为这种危及生命的疾病提供了潜在的治疗点.

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Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...