在患有帕金森病的患者中,喉适应玻尿酸性质
Shakeela Saleem1, Anna Miles2, Jacqueline Allen3
1Speech Science, School of Psychology, The University of Auckland, B072, Level 2, Building 507, Grafton Campus, Park Road, Private Bag 92019, Auckland, New Zealand. fabd416@aucklanduni.ac.nz.
概括
高分辨率人计显示了帕金森病 (PD) 早期吞变化. 这些压力指标的变化与患者报告的困难相关,有助于诊断和治疗规划PD的食障碍.
科学领域:
- 神经学 神经学
- 胃肠病学 胃肠病学
- 语音语言病理学 语言病理学
背景情况:
- 缺食症是帕金森病 (PD) 中普遍存在且经常被低诊断的疾病.
- 高分辨率计量 (HRM) 提供了对喉吞功能的详细评估,但其在PD中的应用没有得到广泛的记录.
- 了解PD中的客观吞指标对于及时干预至关重要.
研究的目的:
- 在患有帕金森病的个体中使用高分辨率计量仪检查吞压力指标.
- 探索球体体积和粘度对喉收缩模式的影响.
- 为了与患者报告的结果和视频光镜评估相关联的测量结果.
主要方法:
- 使用HRM的固态导管记录喉吞压力在各种玻尿酸体积 (5-20毫升) 和粘度 (IDDSI 0,2,4).
- 通过视频光学评估透吸收严重程度,并使用EAT-10和PDQ-8问卷收集患者报告的数据.
- 使用Swallow GatewayTM量化分析了人测数据,并使用通用线性模型将指标与规范值进行了比较.
主要成果:
- 显而易见的是异常的食道上 (UES) 放松和张张,由高集成的放松压力和低的最大入口 (MaxAdm) 表示.
- 观察到喉收缩率升高和吞后ESU收缩率增加,特别是在使用较薄的液体时.
- 玻尿酸体积和粘度显著影响了计时指标,UES峰值压力因玻尿酸粘度而异.
结论:
- 在帕金森病患者中,可识别与玻尿酸性质相关的早期食管收缩变化.
- 这些客观发现与自我报告的吞功能的微妙下降有关.
- 人口测量评估为在帕金森病中诊断和管理食障碍提供了宝贵的见解.
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