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Updated: Jun 24, 2025

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肥胖会诱导巨细胞的PD-1抑制抗瘤免疫力

Jackie E Bader1, Melissa M Wolf1, Gian Luca Lupica-Tondo1

  • 1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.

Nature
|June 12, 2024
PubMed
概括

肥胖会诱导与瘤相关的巨细胞 (TAMs) 的PD-1表达,从而降低抗瘤免疫力. 阻断PD-1可增强巨细胞代谢和T细胞激活,改善肥胖患者的癌症免疫治疗反应.

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