传统的韩国饮食高含单碳营养素增加全球DNA甲基化:对表观遗传饮食的影响
Sukyung Chun1, Min Jung Kim2, Phil-Kyung Shin3
1Department of Gastroenterology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, 13496, South Korea.
European journal of nutrition
|June 12, 2024
概括
传统的韩国饮食,富含单碳营养素,显著增加了女性的全球DNA甲基化. 这表明一种表观遗传途径,K饮食可能会对健康产生积极影响.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 营养科学 营养科学
- 人类健康 人类健康 人类健康
背景情况:
- 饮食通过诸如DNA甲基化之类的表观遗传机制显著影响健康和疾病.
- 传统的韩国饮食 (K-饮食) 具有较高的植物食物摄入量和较低的卡路里和动物脂肪的特点.
- 一碳代谢在DNA甲基化过程中起着至关重要的作用.
研究的目的:
- 研究K饮食对全球DNA甲基化的表观遗传影响.
- 探索单碳新陈代谢在调解K饮食对DNA甲基化影响中的作用.
主要方法:
- 一项涉及52名女性的交叉研究,将4周的K饮食与4周的控制饮食进行比较.
- 测量临床参数,营养摄入量,血清单碳代谢物和外围单核细胞全球DNA甲基化.
- 采用超高性能液态色谱法-并联质谱法进行代谢物和甲基化分析.
主要成果:
- 与对照组相比,K饮食组的叶酸,B6,B12,血清素和胆摄入量较高,甲因摄入量较低.
- 在K饮食组中观察到血5-甲基四基酸盐的显著增加和L-homocysteine的减少.
- 全球DNA甲基化在K饮食组显著增加 (从6.70%增加到9.45%),但在对照组没有.
结论:
- 富含单碳营养素的K饮食增强了全球DNA甲基化状态.
- 这种表观遗传修饰表明K饮食可能带来健康益处的机制.
- 这些发现突显了K饮食在通过表观遗传调节促进健康方面的潜在作用.
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