APOA5多态性和对代谢综合征的易感性之间的关联:系统性审查和元分析
Sima Mozafari1, Marziyeh Ashoori2, Seyed Mahdi Emami Meybodi1
1Yazd Cardiovascular Research Center, Non-Communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Afshar Hospital, Jomhouri Blvd., Yazd, 8917945556, Iran.
阿波利波蛋白A5 (APOA5) 基因的遗传变异,特别是rs662799和rs651821,与更高的代谢综合征 (MetS) 风险有关. 需要进一步的研究来证实这些发现在更大的群体.
科学领域:
- 遗传学 遗传学 是一个
- 代谢疾病 代谢疾病
- 人口健康 人口健康
背景情况:
- 关于阿波利波蛋白A5 (APOA5) 遗传多态和代谢综合征 (MetS) 易感性之间的关联,存在相互矛盾的结果.
- 对观察性研究进行了元分析,以澄清这种关系.
研究的目的:
- 评估APOA5基因多态化与代谢综合征 (MetS) 患病率之间的关联.
- 综合现有观察性研究的证据,以更清楚地了解对MetS的遗传联系.
主要方法:
- 在PubMed,Web of Science,Embase和Scopus数据库中进行了全面的文献搜索,截至2024年4月.
- 使用随机效应模型计算赔率比率 (OR) 和95%置信区间 (CI).
- 使用子组和灵敏度分析来评估异质性的潜在来源.
主要成果:
- 分析包括了30项研究,其中有54,986名参与者 (25341例MetS病例,29645例对照).
- APOA5多态 rs662799和rs651821显著与MetS患病率增加约1.5倍的可能性相关 (OR=1.42,95% CI: 1.32-1.53;OR=1.50,95% CI: 1.36-1.65).
- 基因变异rs3135506和rs2075291也显示出MetS的更高流行率,而rs126317没有显示出显著的关联.
结论:
- APOA5基因的促进子和编码区域的多态性与成年人中MetS患病率的增加有关.
- 识别具有这些遗传变异的个体可能有助于早期发现疾病和预防策略.
- 建议进行进一步的大规模,精心设计的研究,以证实这些发现,因为样本大小的限制和观察到的异质性.
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