对于患有创伤后应激障碍的成年人进行密集与每周递送的长期暴露的单盲,并行组,随机,受控优越性试验的研究方案
Maria Bragesjö1, Brooke Fina2, Ekaterina Ivanova3
1Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden. maria.bragesjo@ki.se.
Trials
|June 12, 2024
概括
强烈长期暴露 (iPE) 治疗可能会降低创伤后应激障碍 (PTSD) 学率并改善恢复. 本研究将iPE与标准PE进行比较,以评估其在临床环境中的有效性.
科学领域:
- 精神病学和行为健康
- 临床心理学 临床心理学
- 创伤研究 创伤研究
背景情况:
- 长期暴露 (PE) 疗法是创伤后应激障碍 (PTSD) 的第一线治疗方法.
- 高退学率 (30-51%) 和长时间的治疗时间限制了PE的有效性.
- 需要PTSD治疗方法,降低中断率和更快的恢复速度.
研究的目的:
- 为了比较PE (iPE) 的密集交付格式与标准的每周PE会话.
- 评估iPE在减少PTSD症状和改善患者治疗结果方面的有效性.
- 评估二次结果,包括抑郁症,生活质量和成本效益.
主要方法:
- 一个单盲,随机对照试验,有140名参与者.
- 主要结局:对DSM-5 (CAPS-5) 评分的临床医生管理的PTSD尺度的变化.
- 二次结果:自我评估的PTSD/复杂的PTSD症状,抑郁,生活质量,恢复速度,成本,退学率和不良事件.
主要成果:
- 该部分应在研究结束并可获得结果后填写.
结论:
- 这项研究是第一个在精神病室门诊环境中比较iPE与标准PE的研究.
- 优势包括临床实施,广泛的资格和黄金标准评估.
- 潜在的挑战包括参与者招募,留住和治疗师坚持.
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