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相关概念视频

Spongy Bone01:09

Spongy Bone

4.3K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
4.3K
Compact Bone01:27

Compact Bone

11.4K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
11.4K
Bone Remodeling01:40

Bone Remodeling

38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

3.4K
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
3.4K
Bone Markings01:26

Bone Markings

5.3K
Bones have various surface features that help form joints and attach to other soft tissues. Depending on the function, bone markings are categorized into articulating projections, processes for attachment, depressions, and openings.
Articulating Projections
Articulating projections are found where two bones meet to form a joint. These structures are usually found at the ends of bones. The largest articulation is a rounded projection called the head, supported by a narrow neck at the ends of...
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Bone Structure01:55

Bone Structure

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Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
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相关实验视频

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Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics
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骨器官轴:双向交叉的交叉轴:双向交叉的交叉轴.

An-Fu Deng1,2, Fu-Xiao Wang1,2, Si-Cheng Wang1,2,3

  • 1Institute of Translational Medicine, Organoid Research Center, Shanghai University, Shanghai, 200444, China.

Military Medical Research
|June 12, 2024
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概括

骨分泌骨基因以支持器官功能,而器官影响骨健康. 本综述探讨了这种骨器官交叉,包括细胞外囊泡,用于疾病洞察和先进的体外模型.

关键词:
双向交叉通道的双向交叉通道骨器官轴 骨器官轴细胞因子 (cytokines) 是一种细胞因子.细胞外囊泡中的细胞外囊泡.激素 这些激素.它的代谢物是代谢物.骨质氨基酶 (Osteokines) 是一种蛋白质.

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Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
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科学领域:

  • 内分泌学和新陈代谢学
  • 细胞生物学 细胞生物学
  • 生物医学工程 生物医学工程

背景情况:

  • 骨提供结构性支持,并分泌细胞因子 (骨基因),对器官功能和恒温至关重要.
  • 骨和其他器官之间存在双向交叉声,影响骨发育和全身健康.
  • 这种复杂的骨 - 器官轴相互作用仍然不完全理解,缺乏系统性审查.

研究的目的:

  • 阐明骨和器官之间的双向通信,重点关注骨基因的作用.
  • 突出突出细胞外囊泡 (EVs) 在骨器官轴中的功能.
  • 探索其对开发先进的体外模型 (如芯片上的骨头和组合物) 的影响.

主要方法:

  • 对有关骨器官交叉的现有文献进行系统审查.
  • 分析骨基因和细胞外囊泡在调解这些相互作用中的作用.
  • 探索这些相互作用对疾病机制和治疗策略的生理相关性.

主要成果:

  • 由骨分泌的骨质氨基酸极大地调节器官功能和全身平衡.
  • 器官通过分泌的因素相互影响骨重塑和发育.
  • 细胞外囊泡在骨-器官通信中发挥着重要的,以前被低估的作用.

结论:

  • 了解骨-器官轴交叉,包括骨基因和EV,对于理解系统性疾病至关重要.
  • 这种知识对于设计研究和药物发现的生理学上相关的体外模型至关重要.
  • 该综述为针对骨-器官轴的新型诊断和治疗方法提供了理论基础.