初级甲状腺功能障碍症中的生育能力和怀孕结果:来自大量保险人群的观察
Vivek R Sant1, Hui Zhou2,3, Mengnan M Zhou2
1Division of Endocrine Surgery, UT Southwestern Medical Center, Dallas, TX 75390, USA.
The Journal of clinical endocrinology and metabolism
|June 13, 2024
概括
与没有这种情况的女性相比,患有原发性副甲状腺炎症 (PHPT) 的女性经历了类似的怀孕率和结果. 怀孕期间的甲状腺切除术是安全的,特别是对于那些水平较高的人来说.
科学领域:
- 内分泌学 在内分泌学.
- 产科 产科 产科 产科 产科
- 生殖健康 生殖健康
背景情况:
- 原发性副甲状腺功能障碍症 (PHPT) 已被有争议地与不利的孕产妇和新生儿结局联系在一起.
- 以前的人口研究对PHPT对怀孕的影响产生了相互矛盾的结果.
研究的目的:
- 为了比较具有和没有PHPT的妇女的孕产妇,怀孕和新生儿结局.
- 评估在怀孕期间侧甲状腺切除术的安全性和有效性.
主要方法:
- 在南加利福尼亚州进行的回顾性匹配队列研究 (2005-2020).
- 包括18-44岁的女性,PHPT与优血症对照相匹配1:3.
- 评估怀孕率,堕胎率,孕产妇并发症和新生儿后果.
主要成果:
- 在PHPT和对照组之间的怀孕率没有显著差异 (10.6%对12.8%).
- 类似的活产率 (79.3%与88.0%) 和新生儿结局.
- 在怀孕期间的甲状腺切除术显示,在<11.5 mg/dL的妇女中,没有自发流产.
结论:
- PHPT似乎没有影响怀孕率或结果.
- 在怀孕第二个三个月之前或期间进行甲状腺切除术是一种安全有效的策略.
- 管理较高的水平 (≥11.5 mg/dL) 对于成功的妊娠结果至关重要.
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