合成,表征和稳定性优化,使用各种水友性聚合物的伊布罗共晶
Ayesha Hassan1, Jamshaid Ali Khan1, Fazli Nasir1
1Department of Pharmacy, University of Peshawar, Peshawar, KPK, Pakistan.
Current pharmaceutical design
|June 13, 2024
概括
这项研究使用水友性聚合物稳定了使用水友性聚合物在片中的布洛芬尼古丁胺 (IBU-NIC) 协晶,与市场上的品牌相比,显著提高了药物溶解率.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 晶可以改善溶解不良药物的传递,但在溶解时可能会变得不成比例.
- 稳定固体剂量形式 (如片剂) 中的共晶对于有效的药物输送至关重要.
- 为了这项研究,合成了布洛芬-尼古丁胺胺 (IBU-NIC) 共同晶体.
研究的目的:
- 为了稳定药片配方中的布洛芬尼古丁胺胺 (IBU-NIC) 共同晶体.
- 为了提高布洛芬共晶的溶解率和可溶性.
- 评估水友性聚合物在溶解过程中稳定共晶的有效性.
主要方法:
- 通过缓慢和快速的溶剂蒸发来合成IBU-NIC共晶体.
- 使用粉末X射线衍射 (PXRD),FTIR,DSC,TGA和光学显微镜进行表征.
- 使用IBU-NIC共晶体和水友聚合物 (HPMC,PVP K-30,PVP K-90) 的药片配方的制备和溶解试验.
主要成果:
- 与母药伊布洛芬相比,IBU-NIC共晶体显示出增强的溶解性.
- 使用水友聚合物的三种药片配方 (F1,F2,F3) 在溶解过程中稳定了共晶体.
- 所有配方的药物释放率 (92.30-99.88%) 与市场上销售的品牌BRUFEN® (79.61%) 相比,在60分钟内显著提高 (p<0.001).
结论:
- 水友性聚合物有效地稳定了药片配方中的IBU-NIC共晶体.
- 在没有相变的情况下,可实现共晶的溶解率的显著增加.
- 开发的药片配方显示出改善可溶性较差药物的输送的潜力.
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