慢性C2半截裂后自发呼吸恢复的性别差异
Taylor C Holmes1, Nicole M Popp1, Carley F Hintz1
1Exercise and Rehabilitation Science Program, Department of Physical Therapy, Marquette University, Milwaukee, Wisconsin, United States.
Journal of applied physiology (Bethesda, Md. : 1985)
|June 13, 2024
概括
雌性动物在C2半切除 (C2Hx) 后的慢性呼吸系统恢复比雄性更好,有明显的隔膜肌肉变化. 了解这些性别差异对于开发有效的脊髓损伤疗法至关重要.
科学领域:
- 神经科学是一个神经科学.
- 呼吸系统生理学 呼吸系统生理学
- 脊髓损伤研究 脊髓损伤研究
背景情况:
- C2半截裂 (C2Hx) 导致呼吸系统缺陷,由于卵巢激素的作用,女性的短期恢复更好.
- 在C2Hx后自发呼吸恢复的长期基于性别的差异仍然不清楚.
研究的目的:
- 在C2Hx后8周内全面描述性取决于性别的呼吸神经肌肉恢复.
- 在慢性C2Hx.x之后,调查隔膜肌肉形态中的性别差异.
主要方法:
- 在清醒的动物中进行通风和隔膜电肌图 (EMG) 的纵向研究.
- 在麻醉的动物中评估动力输出.
- 在C2Hx后的雄性和雌性动物中,隔膜肌肉组织学.
主要成果:
- 与男性相比,女性在亚急性和慢性时间点的潮体积和每分钟通风的恢复更大.
- 在两性之间,eupneic隔膜EMG和phrenic运动幅度是相似的.
- 雌性在深呼吸 (叹息) 时表现出较大降低的双侧腹膜EMG,并表现出肌肉纤维缩和重塑.
结论:
- 在C2Hx后的慢性呼吸系统恢复和隔膜肌肉形态方面存在显著的性别差异.
- 这些发现强调了需要将两性纳入研究,以告知脊髓损伤 (SCI) 的性别特定治疗策略的必要性.
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