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Updated: Aug 12, 2026

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
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赫尔姆-GPT:使用生成式预训练变压器 de novo宏环设计

Xiaopeng Xu1,2, Chencheng Xu1,2, Wenjia He1,2

  • 1Computer Science Program, Computer, Electrical and Mathematical Science and Engineering (CEMSE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Makkah, Kingdom of Saudi Arabia.

Bioinformatics (Oxford, England)
|June 13, 2024
PubMed
概括

HELM-GPT是一种新的计算方法,用于设计宏环以向细胞内蛋白质. 这种方法优化了的特性,如细胞透性和结合亲和力,用于潜在的癌症疗法.

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Peptidoglycan Synthesis01:28

Peptidoglycan Synthesis

Structure of PeptidoglycanPeptidoglycan is a vital structural component of the bacterial cell wall, providing mechanical strength and shape to the cell. It consists of repeating units of two sugars—N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM)—linked by β-1,4 glycosidic bonds. These sugar chains are cross-linked by short peptide chains, forming a mesh-like polymer that surrounds the bacterial plasma membrane.Cytoplasmic Phase – Precursor SynthesisPeptidoglycan biosynthesis begins in...